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EBOLA:FAVIPIRAVIR.
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Favipiravir also known as T-705 is an experimental anti-viral drug with activity against many RNA VIRUSES. It, like some other experimental antiviraldrugs (T-1105 and T-1106), is a pyrazinecarboxamide derivative. Favipiravir is active against influenza viruses,West Nile virus,yellow fever virus,foot and mouth disease virus as well as other flaviviruses,arenaviruses,bunyaviruses and alphaviruses. The mechanism of its actions is thought to be related to the selective inhibition of viral RNa-dependent RNA polymerase. Favipiravir does not inhibit RNA of DNA synthesis in mammalian cells and is not toxic to them.
The advantage of using favipiravir in an Ebola outbreak is that it
has already been extensively tested for use as an anti-viral in human
trials for influenza. The drug is now in a U.S. final-stage trial for
treating influenza.
In addition, the drug is a pill, unlike the
cocktail of injected antibodies administered to two Americans who got
Ebola. This means it may be easier to use in rural locations with
limited medical infrastructure.
Photographer:EPA
Liberian nurses carry an Ebola victim from a house for burial in the Banjor Community.
On August 5, a spokeswoman for MediVector declined to
comment on the possibility of human use of the drug in Ebola, and
deferred questions on subject to the Department of Defense.
Civil service instigates investigation into leaked memo from Foreign Office about supposed comments made in February Scotland’s first minister, Nicola Sturgeon, with David Cameron in her office at the Scottish parliament earlier this year. Photograph: WPA Pool/Getty A civil service inquiry into a leaked memo which claimed that Nicola Sturgeon privately wanted to see David Cameron remain in power after the general election has been instigated following calls from the First Minister. Ms Sturgeon described the allegation as “100% untrue” and accused Whitehall of “dirty tricks”.
According to the index, the prevalence of modern slavery is highest in… Mauritania Haiti Pakistan India Nepal Moldova Benin Cote d’Ivoire The Gambia Gabon However, when considered in absolute terms, the countries with the highest numbers of enslaved people are… India China Pakistan Nigeria Ethiopia Russia Thailand Democratic Republic of the Congo Myanmar Bangladesh Taken together, these ten countries account for 76% of the total estimate of 29.8 million enslaved people. * The Index provides an estimated range of the number of people in modern slavery, for each of the 162 countries covered by the Index. The lower range of the estimate is 28.3 million in modern slavery, and the upper range of the estimate is 31.3 million in modern slavery. The figure of 29.8 million is the mean of these estimates. Index 2013 The Global Slavery Index provides a ranking of 16...
A WHO staff gets her body temperature checked at Lungi Airport, Freetown, Sierra Leone. Photo: WHO Sierra Leone Misinformation about Ebola can only exacerbate an already fragile situation, said United Nations officials at the highest level today, urging international action and solidarity to help West African countries deal with the myriad health and socioeconomic impacts of current outbreak of the deadly virus. “The fear factor plays a strong role in the crisis. I encourage the Member States and businesses and individuals as well, to take decisions based on scientific evidence, not on fear,” urged UN Deputy Secretary-General Jan Eliasson, as he opened a high-level briefing for Member States at UN Headquarters in New York on the Organization's response to the unprecedented outbreak. The latest number of Ebola virus disease (EVD) cases in affected countries Guinea, Liberia, Nigeria, and Sierra Leone, stands at 3,069, with over 1,552 deaths,...
