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EBOLA:FAVIPIRAVIR.
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Favipiravir also known as T-705 is an experimental anti-viral drug with activity against many RNA VIRUSES. It, like some other experimental antiviraldrugs (T-1105 and T-1106), is a pyrazinecarboxamide derivative. Favipiravir is active against influenza viruses,West Nile virus,yellow fever virus,foot and mouth disease virus as well as other flaviviruses,arenaviruses,bunyaviruses and alphaviruses. The mechanism of its actions is thought to be related to the selective inhibition of viral RNa-dependent RNA polymerase. Favipiravir does not inhibit RNA of DNA synthesis in mammalian cells and is not toxic to them.
The advantage of using favipiravir in an Ebola outbreak is that it
has already been extensively tested for use as an anti-viral in human
trials for influenza. The drug is now in a U.S. final-stage trial for
treating influenza.
In addition, the drug is a pill, unlike the
cocktail of injected antibodies administered to two Americans who got
Ebola. This means it may be easier to use in rural locations with
limited medical infrastructure.
Photographer:EPA
Liberian nurses carry an Ebola victim from a house for burial in the Banjor Community.
On August 5, a spokeswoman for MediVector declined to
comment on the possibility of human use of the drug in Ebola, and
deferred questions on subject to the Department of Defense.
Civil service instigates investigation into leaked memo from Foreign Office about supposed comments made in February Scotland’s first minister, Nicola Sturgeon, with David Cameron in her office at the Scottish parliament earlier this year. Photograph: WPA Pool/Getty A civil service inquiry into a leaked memo which claimed that Nicola Sturgeon privately wanted to see David Cameron remain in power after the general election has been instigated following calls from the First Minister. Ms Sturgeon described the allegation as “100% untrue” and accused Whitehall of “dirty tricks”.
Health workers take passengers' temperatures infrared digital laser thermometers at the Felix Houphouet Boigny international airport in Abidjan on Aug. 13, 2014. Ivory Coast on Monday banned air travellers from Guinea, Liberia and Sierra Leone, the three countries worst-hit by the Ebola outbreak, and ordered its flagship carrier Air Cote d'Ivoire to cease flights to and from them. Reuters/Luc Gnago Guinea, one of the worst-hit West African nations in the ongoing Ebola outbreak, announced a state of emergency Wednesday. The World Health Organization, or WHO, also said that four new people died in Guinea between Aug. 10 and Aug. 11. The total death count in Guinea from the latest epidemic was estimated at 377 by WHO while the number of cases reported had risen to ...
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