Doctor treating Ebola with HIV drug.
- Dr. Gorbee Logan tried using lamivudine against Ebola out of sheer desperation. Only two out of 15 patients taking it died -- far lower than the average death rate. Logan read about the medication and similarities between Ebola and HIV in a medical journal
Dr. Gorbee Logan has
given the drug, lamivudine, to 15 Ebola patients, and all but two
survived. That's about a 13% mortality rate.
Across West Africa, the virus has killed 70% of its victims.
Outside Logan's Ebola
center in Tubmanburg, four of his recovering patients walk the grounds,
always staying inside the fence that separates the Ebola patients from
everyone else.
"My stomach was hurting; I
was feeling weak; I was vomiting," Elizabeth Kundu, 23, says of her
bout with the virus. "They gave me medicine, and I'm feeling fine. We
take it, and we can eat -- we're feeling fine in our bodies."
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Kundu and the other 12
patients who took the lamivudine and survived, received the drug in the
first five days or so of their illness. The two patients who died
received it between days five and eight.
"I'm sure that when [patients] present early, this medicine can help," Logan said. "I've proven it right in my center."
Logan is mindful that lamivudine can cause liver and other problems, but he says it's worth the risk since Ebola is so deadly.
He also knows American
researchers will say only a real study can prove effectiveness. That
would involve taking a much larger patient population and giving half of
them lamivudine and the other half a placebo.
"Our people are dying
and you're taking about studies?" he said. "It's a matter of doing all
that I can do as a doctor to save some people's lives.
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Logan said he got the
idea to try lamivudine when he read in scientific journals that HIV and
Ebola replicate inside the body in much the same way.
"Ebola is a brainchild of HIV," he said. "It's a destructive strain of HIV."
At first he tried a drug
called acyclovir, which is often given to HIV patients to treat
infections that occur with their weakened immune systems. But it didn't
seem to be effective. Then he tried lamivudine on a health care worker
who'd become ill, and within a day or two he showed signs of improvement
and survived.
Dr. Anthony Fauci,
director of the National Institute of Allergy and Infectious Diseases
says that theoretically, Logan's approach has some merit. Lamivudine is a
nucleocide analog, and other drugs in this class are being studied to
treat Ebola.
Fauci asked CNN to give Logan his email address, saying perhaps his lab could do some follow up work.
Logan says he plans to email Fauci this weekend.CNN.